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A strategy to synthesize water‐soluble and fluorescent flavonoid‐silica nanocomposites (FSiNCs) simultaneously featuring anti‐tumor and anti‐bacterial abilities is developed. Furthermore, it is demonstrated that the therapeutic effects of FSiNCs are associated with the selective accumulation of reactive oxide species in both tumor and bacteria cells. Following that, the resultant FSiNCs are incorporated...
Natural bacteria are interesting subjects for cancer treatments owing to their unique autonomy‐driven and hypoxic target properties. Genetically modified bacteria (such as bacteria with msbB gene and aroA gene modifications) can effectively cross sophisticated physiological barriers and transport antitumor agents into deep tumor tissues, and they have good biosafety. Additionally, bacteria can secrete...
Ultrasmall nanoparticles are often grouped under the broad umbrella term of “nanoparticles” when reported in the literature. However, for biomedical applications, their small sizes give them intimate interactions with biological species and endow them with unique functional physiochemical properties. Carbon quantum dots (CQDs) are an emerging class of ultrasmall nanoparticles which have demonstrated...
Endogenous targeted radiotherapy is emerging as an integral modality to treat a variety of cancer entities. Nevertheless, despite the positive clinical outcome of the treatment using radiolabeled peptides, small molecules, antibodies, and nanobodies, a high degree of hepatotoxicity and nephrotoxicity still persist. This limits the amount of dose that can be injected. In an attempt to mitigate these...
Ultrasmall gold nanoparticles (2 nm) easily penetrate the membranes of intestinal murine epithelial cells (MODE‐K) and colorectal cancer cells (CT‐26). They are also taken up by 3D spheroids (400 µm) of these cell types and primary gut organoids (500 µm). In contrast, dissolved dyes are not taken up by any of these cells or 3D structures. The distribution of fluorescent ultrasmall gold nanoparticles...
Ultrasmall Gold Nanoparticles
Three‐dimensional cell culture models represent a bridge between conventional two‐dimensional cell culture studies and in‐vivo animal experiments. In article number 2201167, Astrid M. Westendorf, Matthias Epple, and co‐workers demonstrate the cytostatic action of doxorubicin‐carrying ultrasmall gold nanoparticles, including their superior ability to enter the three‐dimensional...
Boron neutron capture therapy (BNCT) is a non‐invasive cancer treatment with little adverse effect utilizing nuclear fission of 10B upon neutron irradiation. While neutron source has been developed from a nuclear reactor to a compact accelerator, only two kinds of drugs, boronophenylalanine and sodium borocaptate, have been clinically used for decades despite their low tumor specificity and/or retentivity...
Neuroblastoma Therapy
In article number 2201671, Zhen Liu and co‐workers construct polysialic acid‐targeting nano‐missiles via a molecular imprinting strategy using oligosialic acid containing 4‐7 units digested from polySia as the template. Effective targeted photothermal therapy of neuroblastoma is achieved using nano‐missiles loaded with the near‐infrared fluorescent reactive dye indocyanine green...
Exploring new targets and developing novel targeted therapies are urgently needed for neuroblastoma therapy. Polysialic acid (polySia), a linear homopolymer of sialic acid units that correlates well with tumor progression and poor prognosis, has emerged as a potential target for neuroblastoma. However, the lack of polySia‐specific binding reagents has severely limited the development of polySia‐targeting...
The assembly of adenosine triphosphate (ATP)‐responsive and miRNA‐responsive DNA tetrahedra‐functionalized carboxymethyl cellulose hydrogel microcapsules is presented. The microcapsules are loaded with the doxorubicin‐dextran drug or with CdSe/ZnS quantum dots as a drug model. Selective unlocking of the respective microcapsules and the release of the loads in the presence of ATP or miRNA‐141 are demonstrated...
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