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Multiscale polymer engineering, involving chemical modification to control their triboelectric polarities as well as physicomechanical modification to maximize charge transfer and structural durability, is paramount to developing a high‐performance triboelectric nanogenerator (TENG). This report introduces a highly efficient and comprehensive strategy to engineer high‐performance TENG based on multifunctional...
Electrosprayed microspheres for bone regeneration are conventionally restricted by the lack of osteogenic modulation for both encapsulated stem cells and surrounding cells at the defect site. Here, sodium alginate microspheres encapsulating L‐arginine doped hydroxyapatite nanoparticles (Arg/HA NPs) and bone mesenchymal stem cells (BMSCs) as regeneration‐enhancer‐element reservoirs (Arg/HA‐SA@BMSC)...
Human cells encounter dynamic mechanical cues in healthy and diseased tissues, which regulate their molecular and biophysical phenotype, including intracellular mechanics as well as force generation. Recent developments in bio/nanomaterials and microfluidics permit exquisitely sensitive measurements of cell mechanics, as well as spatiotemporal control over external mechanical stimuli to regulate cell...
Owing to the development of nanotechnology and noninvasive treatment, thermal therapy in combination with external stimuli has been applied for tissue engineering and regenerative medicine (TERM), which has attracted more and more attention in recent years. In this review, the recent progress of applying a variety of non‐invasive thermal therapeutic modalities for TERM, including photothermal therapy,...
Cardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic stroke are the leading causes of death worldwide, resulting in 16% and 11% of deaths globally. Although several therapeutic approaches are presented over the years, the continuously increasing mortality rates suggest the need...
Vascularized osteogenesis is essential for successful bone regeneration, yet its realization during large size bone defect healing remains challenging due to the difficulty to couple multiple biological processes. Herein, harnessing the intrinsic angiogenic potential of vascular derived extracellular matrix (vECM) and its specific affinity to growth factors, a vECM/GelMA based hybrid hydrogel delivery...
Mesenchymal stem cells (MSCs) have a demonstrated value for acute liver failure (ALF) regeneration, while their delivery stratagems with long‐term biological functions, low immune response, and high biocompatibility are still a challenge. Here, a lipopolysaccharide (LPS)‐loaded photoresponsive cryogel porous microcarrier (CPM) for MSCs delivery and colonization is presented to promote defect liver...
The cell microenvironment plays a crucial role in regulating cell behavior and fate in physiological and pathological processes. As the fundamental component of the cell microenvironment, extracellular matrix (ECM) typically possesses complex ordered structures and provides essential physical and chemical cues to the cells. Hydrogels have attracted much attention in recapitulating the ECM. Compared...
Inner Ear Therapy
In article number 2106591, Bin Ye, Wenguo Cui, Mingliang Xiang, and co‐workers construct a mussel‐inspired injectable hydrogel microsphere loading Ebselen liposomes that adheres to the cochlea round windows membrane (RWM). The positively charged primary amine groups through electrostatic interaction and the catechol groups through high‐strength coordination bonds and hydrogen bonds...
Biocompatible Conductive Inks
In article number 2107099, Cunjiang Yu and co‐workers report the recent development of a conductive ink that is fully biocompatible at the cell, tissue, and organ levels. It also allows for conformal interfacing with human skin for high‐fidelity electrophysiological measurements. This cover illustrates the conformal contact of the ink film with skin.
4D bioprinting techniques that facilitate formation of shape‐changing scaffold‐free cell condensates with prescribed geometries have yet been demonstrated. Here, a simple 4D bioprinting approach is presented that enables formation of a shape‐morphing cell condensate‐laden bilayer system. The strategy produces scaffold‐free cell condensates which morph over time into predefined complex shapes. Cell...
Bone Tissue Repair
In article number 2200314, Xin Zhao and co‐workers electrospray microspheres encapsulating stem cells and natural tissue metabolites as regeneration‐enhancer‐element reservoirs to power the inside/outside microsphere cell–cell/cell–material communication for accelerated vascularized bone tissue repair.
Functional microgels are preferred stem cell carriers due to the ease of delivery through minimally invasive injection and seamless integration with the surrounding host tissue. A biostimulatory nanofiber‐hydrogel composite (NHC) has been previously developed through covalently crosslinking a hyaluronic acid hydrogel network with surface‐functionalized poly (ε‐caprolactone) nanofiber fragments. The...
Bone defect regeneration depends on the population and lifespan of M2 macrophages, which are regulated by dual signals generated by the “physical” spatial configuration of biological tissues and “molecular” chemokines. Herein, inspired by the reprogramming of macrophages, immunoengineered porous microspheres are constructed to accelerate bone repair through the regulation of both “physical” and “molecular”...
The regeneration of 3D tissue constructs with clinically relevant sizes, structures, and hierarchical organizations for translational tissue engineering remains challenging. 3D printing, an additive manufacturing technique, has revolutionized the field of tissue engineering by fabricating biomimetic tissue constructs with precisely controlled composition, spatial distribution, and architecture that...
The burden of bone fractures demands development of effective biomaterial solutions, while additional acute events such as noncompressible bleeding further motivate the search for multi‐functional implants to avoid complications including osseous hemorrhage, infection, and nonunion. Bone wax has been widely used in orthopedic bleeding control due to its simplicity of use and conformation to irregular...
Granular hydrogels are an exciting class of microporous and injectable biomaterials that are being explored for many biomedical applications, including regenerative medicine, 3D printing, and drug delivery. Granular hydrogels often possess low mechanical moduli and lack structural integrity due to weak physical interactions between microgels. This has been addressed through covalent inter‐particle...
The unique biological characteristics and promising clinical potential of extracellular vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as important mediators of intercellular communication, naturally secreted EVs have the potential, as innate biotherapeutics, to promote tissue regeneration. Although EVs have emerged as novel therapeutic agents, challenges related...
Urinary‐based infections affect millions of people worldwide. Such bacterial infections are mainly caused by Escherichia coli (E. coli) biofilm formation in the bladder and/or urinary catheters. Herein, the authors present a hybrid enzyme/photocatalytic microrobot, based on urease‐immobilized TiO2/CdS nanotube bundles, that can swim in urea as a biocompatible fuel and respond to visible light. Upon...
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