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Metal peroxide nanoparticles designed to elevate the oxidative stress are considered a promising nanotherapeutics in biomedical applications, including chemotherapy, photodynamic therapy, and bacterial disinfection. However, their lack of specificity towards the therapeutic target can cause toxic side effects to healthy tissues. Here, silver peroxide nanoparticles (Ag2O2 NPs) capable of controlled...
Hepatic Ischemia‐Reperfusion Injury Management
Selenium‐doped carbon quantum dots (Se‐CQDs) with excellent anti‐oxidation capability protect hepatocytes from apoptosis by limiting damage from oxidative stress. Se‐CQDs‐lecithin nanoparticles are developed through a supramolecular self‐assembly mainly driven by noncovalent interactions, which effectively scavenge reactive oxygen species and inhibit...
Nanomaterials with enzyme‐mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing to their remarkable advantages, such as high stability, easy preparation, and favorable catalytic performance. Recently, with the rapid development of nanotechnology and characterization techniques, single atom nanozymes (SAzymes) with atomically dispersed active sites, well‐defined...
Hepatic ischemia‐reperfusion injury (HIRI) is a critical complication after liver surgery that negatively affects surgical outcomes of patients with the end‐stage liver‐related disease. Reactive oxygen species (ROS) are responsible for the development of ischemia‐reperfusion injury and eventually lead to hepatic dysfunction. Selenium‐doped carbon quantum dots (Se‐CQDs) with an excellent redox‐responsive...
As an emerging cancer treatment strategy, ferroptosis is greatly restricted by excessive glutathione (GSH) in tumor microenvironment (TME) and low reactive oxygen species (ROS) generation efficiency. Here, this work designs self‐assembled copper‐alanine nanoparticles (CACG) loaded with glucose oxidase (GOx) and cinnamaldehyde (Cin) for in situ glutathione activated and enzymatic cascade‐enhanced ferroptosis...
Developing effective catalysts to degrade chemical warfare agents is of great significance. Herein, a mesoporous MIL‐101(Cr) composite material dangled with porphyrin molecules (denote as TCPP@MIL‐101(Cr), TCPP = tetra(4‐carboxyphenyl)porphyrin) is reported, which can be used as a heterogeneous photocatalyst for detoxification of mustard gas simulants 2‐chloroethyl ethyl sulfide (CEES) to 2‐chloroethyl...
Cavitation Ablation
In article number 2302744, Zhe Wu, Lang Ma, Qiang Lu, and co‐workers develop an Mn‐coordinated polyphthalocyanine sonocavitation agent that consists of Mn‐phthalocyanine as the catalytic sites and the conjugated layer‐stacked polyphthalocyanine network as the acoustic response group, which will help deepen the understanding of non‐thermal cavitation ablation histotripsy and the...
Non‐invasive cancer treatment strategies that enable local non‐thermal ablation, hypoxia relief, and reactive oxygen species (ROS) production to achieve transiently destroying tumor tissue and long‐term killing tumor cells would greatly facilitate their clinical applications. However, continuously generating oxygen cavitation nuclei, reducing the transient cavitation sound intensity threshold, relieving...
The evolutionary advantages afforded by phytoplankton calcification remain enigmatic. In this work, fluoroelectrochemical experiments reveal that the presence of a CaCO3 shell of a naturally calcifying coccolithophore, Coccolithus braarudii, offers protection against extracellular oxidants as measured by the time required for the switch‐off in their chlorophyll signal, compared to the deshelled equivalents,...
Rabies is a zoonotic neurological disease caused by the rabies virus (RABV) that is fatal to humans and animals. While several post‐infection treatment have been suggested, developing more efficient and innovative antiviral methods are necessary due to the limitations of current therapeutic approaches. To address this challenge, a strategy combining photodynamic therapy and immunotherapy, using a...
Alzheimer's disease (AD) is a severe neurodegenerative condition characterized by inflammation, beta‐amyloid (Aβ) plaques, and neurodegeneration, which currently lack effective treatments. Chiral nanomaterials have emerged as a promising option for treating neurodegenerative disorders due to their high biocompatibility, strong sustained release ability, and specific enantiomer selectivity. The development...
Bacterial infection continues to be an increasing global health problem with the most widely accepted treatment paradigms restricted to antibiotics. However, the overuse and misuse of antibiotics have triggered multidrug resistance of bacteria, frustrating therapeutic outcomes, and leading to higher mortality rates. Even worse, the tendency of bacteria to form biofilms on living and nonliving surfaces...
Cancer Management
Nanomodified electrochemical printed strips might represent a powerful tool for the management of cancer at the diverse stages of malignancy. In particular, the possibility to combine low‐cost electrochemical biosensors with smartphone‐powered potentiostat, opens to wide application not only towards cancer but also towards other field of applications. In article number 2208209, Stefano...
Hydrogen peroxide (H2O2) is a primary reactive oxygen species (ROS) that can act as a chemical signal in developing and progressing serious and life‐threatening diseases like cancer. Due to the stressful nature of H2O2, there is an urgent need to develop sensitive analytical approaches to be applied to various biological matrices. Herein, a portable point‐of‐care electrochemical system based on MXene‐Co...
The contrast agents and tumor treatments currently used in clinical practice are far from satisfactory, due to the specificity of the tumor microenvironment (TME). Identification of diagnostic and therapeutic reagents with strong contrast and therapeutic effect remains a great challenge. Herein, a novel carbon dot nanozyme (Mn‐CD) is synthesized for the first time using toluidine blue (TB) and manganese...
The global pandemic and excessive use of antibiotics have raised concerns about environmental health, and efforts are being made to develop alternative bactericidal agents for disinfection. Metal‐based nanomaterials and their derivatives have emerged as promising candidates for antibacterial agents due to their broad‐spectrum antibacterial activity, environmental friendliness, and excellent biocompatibility...
Iron oxide nanoparticles (IONPs) have garnered significant attention as a promising platform for reactive oxygen species (ROS)‐dependent disease treatment, owing to their remarkable biocompatibility and Fenton catalytic activity. However, the low catalytic activity of IONPs is a major hurdle in their clinical translation. To overcome this challenge, IONPs of different compositions are examined for...
Based on the pathological characteristics of rheumatoid arthritis, including the overproduction of reactive oxygen species (ROS), inflammatory responses, and osteoclast differentiation, a biomimetic multifunctional nanomedicine (M‐M@I) is designed. Iguratimod (IGU) is loaded, which inhibits inflammatory responses and osteoclast differentiation, into mesoporous polydopamine (MPDA), which scavenges...
Mitochondria are core regulators of tumor cell homeostasis, and their damage has become an arresting therapeutic modality against cancer. Despite the development of many mitochondrial‐targeted pharmaceutical agents, the exploration of more powerful and multifunctional medications is still underway. Herein, oxygen vacancy‐rich BiO2‐x wrapped with CaCO3 (named BiO2‐x@CaCO3/PEG, BCP) is developed for...