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Ectopic pregnancy (EP) is the leading cause of maternity‐related death in the first trimester of pregnancy. Approximately 98% of ectopic implantations occur in the fallopian tube, and expedient management is crucial for preventing hemorrhage and maternal death in the event of tubal rupture. Current ultrasound strategies misdiagnose EP in up to 40% of cases, and the failure rate of methotrexate treatment...
Targeted liposomes, as a promising carrier, have received tremendous attention in COVID‐19 vaccines, molecular imaging, and cancer treatment, due to their enhanced cellular uptake and payload accumulation at target sites. However, the conventional methods for preparing targeted liposomes still suffer from limitations, including complex operation, time‐consuming, and poor reproducibility. Herein, a...
Theranostics of Thrombosis
In article number 2205744, Hang Thu Ta and co‐workers present a novel nanoparticle (AgIONP) for theranostics of thrombosis. AgIONPs can specifically bind to thrombus. Exposure of AgIONPs to a near‐infrared laser leads to thrombolysis and restoration of the blood flow. AgIONPs can also be used as a multimodal diagnostic agent.
Thrombosis and its complications are responsible for 30% of annual deaths. Limitations of methods for diagnosing and treating thrombosis highlight the need for improvements. Agents that provide simultaneous diagnostic and therapeutic activities (theranostics) are paramount for an accurate diagnosis and rapid treatment. In this study, silver‐iron oxide nanoparticles (AgIONPs) are developed for highly...
Photothermal therapy (PTT) has attracted considerable attention in recent years due to their unique advantages in minimal invasiveness and spatiotemporal selectivity. However, the fabrication procedures of PTT agents frequently require complex chemical and/or physical methods that involves harsh and environmentally hazardous conditions. Here, a genetically engineered bacterium is developed to synthesize...
Photoacoustic imaging (PAI) and imaging‐guided photothermal therapy (PTT) in the second near‐infrared window (NIR‐II, 1000–1700 nm) have received increasing attention owing to their advantages of greater penetration depth and higher signal‐to‐noise ratio. Plasmonic nanomaterials with tunable optical properties and strong light absorption provide an alternative to dye molecules, showing great prospects...
Spinal Cord Injuries
In article number 2207888, Xianjin Du, Jian Zhang, Hongsheng Lin, Yuhui Liao, and co‐workers design an emergency treatment and photoacoustic severity assessment (ETPSA) strategy for spinal cord injury (SCI) based on the selenium (Se) matrix antioxidant system Se@BDP‐DOH nanoparticles, which can real‐time evaluate the severity of SCI using photoacoustic signals and simultaneously...
Spinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and irreversible pathological deterioration of the central nervous system. Thus, preventing secondary injuries caused by reactive oxygen species (ROS), as well as monitoring and assessing the recovery from SCI are critical for the emergency treatment of SCI. Herein, an emergency treatment strategy is developed for SCI...
Deep Tumor Penetration
The mAlb780@CaP, when transported to the tumor site, triggers a highly efficient process of transcytosis facilitated by caveolae‐mediated endocytosis and calcium ion‐induced exocytosis. This mechanism yields a versatile platform for photoacoustic (PA) imaging‐guided interventions, enhancing the treatment efficacy for solid tumors by deep tissue penetration. More details can...
Transcytosis is an active transcellular transportation pathway that has garnered interest for overcoming the limited deep penetration of nanomedicines in solid tumors. In this study, a charge‐convertible nanomedicine that facilitates deep penetration into solid tumors via transcytosis is designed. It is an albumin‐based calcium phosphate nanomedicine loaded with IR820 (mAlb‐820@CaP) for high‐resolution...
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