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A stomach functional imaging technique based on photoacoustics achieves noninvasive gastric acid secretory assessment utilizing pH‐responsive polyaniline nanoprobes. A testing protocol mimicking clinical practice is established using a mouse model. After imaging, the nanoprobes are excreted outside the body without inducing systematic toxicity. Further optimization and translation of this technology...
As one of the reduction species, glutathione (GSH) plays a tremendous role in regulating the homeostasis of redox state in living body. Accurate imaging of GSH in vivo is highly desired to provide a real‐time visualization of physiological and pathological conditions while it is still a big challenge. Recently developed photoacoustic imaging (PAI) with high resolution and deep penetration characteristics...
In article number 1703400, Quli Fan and co‐workers develop a cyanine derivative‐based nanoprobe with specific GSH sensing capability by taking advantage of the single composition architecture design, which permits noninvasive real‐time ratiometric photoacoustic imaging of GSH in the tumors of living mice.
As conjugated polymer nanoparticles (CPNs) have attracted growing interest as photoacoustic (PA) imaging contrast agents, revelation of the relationship between the molecular structure of conjugated polymers and PA property is highly in demand. Here, three donor–acceptor‐structured conjugated polymer analogs are designed, where only a single heteroatom of acceptor units changes from oxygen to sulfur...
Ectopic pregnancy (EP) is the leading cause of maternity‐related death in the first trimester of pregnancy. Approximately 98% of ectopic implantations occur in the fallopian tube, and expedient management is crucial for preventing hemorrhage and maternal death in the event of tubal rupture. Current ultrasound strategies misdiagnose EP in up to 40% of cases, and the failure rate of methotrexate treatment...
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