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The ultimate goal in the area of drug‐delivery systems is the development of a nanoparticle that can penetrate the endothelial cell monolayer for the targeting of tissue parenchyma. In the present study, we identify a transcytosis‐targeting peptide (TTP) that permits polyethyleneglycol (PEG)‐modified liposomes (PEG‐LPs) to penetrate through monolayers of brain‐derived endothelial cells. These endothelial...
A novel two‐component self‐assembling chimeric peptide is designed where two orthogonal protein folding motifs are linked side by side with precisely defined position relative to one another. The self‐assembly is driven by a combination of symmetry controlled molecular packing, intermolecular interactions, and geometric constraint to limit the assembly into compact dodecameric protein nanoparticles...
Despite nearly a century of clinical use as a blood thinner, heparin's rapid serum clearance and potential to induce severe bleeding events continue to urge the development of more effective controlled delivery strategies. Subcutaneous depots that steadily release the anticoagulant into circulation represent a promising approach to reducing overdose frequency, sustaining therapeutic concentrations...
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation‐induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available to effectively delay IVDD. This study develops a multifunctional full name of PG@Cu nanoparticle network (PG@Cu). A designed pentapeptide,...
Intervertebral Disc Degeneration
In article number 2308167, Pooyan Makvandi, Yunlong Zhou, Aimin Wu, and co‐workers prepared a multifunctional metal polyphenol nanoparticle that exhibited the ability to escape lysosomal capture and effectively targeted mitochondria to scavenge excess reactive oxygen species. The results of in vitro and in vivo experiments showed that the nanoparticles retarded disc...
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