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The brain requires large amounts of amino acids, which normally get across the brain capillaries through transporters and are then used by brain cells. When glioma takes place, tumor cells sitting right outside brain capillaries are always ready to grab the food of brain cells. Based on this, on page 5633, C. Jiang and co‐workers decorate therapeutic nanoparticles with amino acid derivates, making...
Energy metabolism abnormity is one of the most significant hallmarks of cancer. As a result, large amino acid transporter 1 (LAT1) is remarkably overexpressed in both blood‐brain‐barrier and glioma tumor cells, leading a rapid and sufficient substrate transportation. 3CDIT and 4CDIT are originally synthesized by modifying the existing most potent LAT1 substrate. 3CDIT is selected as its higher glioma‐targeting...
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