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Osteosarcoma (OS) is the most serious bone malignancy, and the survival rate has not significantly improved in the past 40 years. Thus, it is urgent to develop a new strategy for OS treatment. Chemodynamic therapy (CDT) as a novel therapeutic method can destroy cancer cells by converting endogenous hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the therapeutic efficacy...
Drug Free Tumor Theranostics
In article number 2205165, Tymish Y. Ohulchanskyy and co‐authors introduce hemoglobin nanocrystals for drug free, synergistic and selective theranostics of colon cancer. After intravenous (i.v.) injection, these nanocrystals target colon tumor and react with tumor‐specific H2S and H2O to enable magnetic resonance imaging guided photothermal therapy and produce •OH for...
The conventional approach in cancer nanomedicine involves advanced drug nanocarriers delivering preloaded therapeutics to targeted tumor sites to maximize drug efficiency. However, both cancer drugs and nanocarriers inevitably produce side effects and systemic toxicity. Herein, hemoglobin nanocrystals (HbC) as drug‐free theranostic nanoformulations with the tumor microenvironment (TME) activated diagnostic...
The establishment of effective antitumor immune responses of vaccines is mainly limited by insufficient priming tumor infiltration of T cells and immunosuppressive tumor microenvironment (TME). Targeting β‐adrenergic receptor (β‐AR) signaling exerts promising benefits on reversing the suppressive effects directly on T cells, but it appears to have considerably limited antitumor performance when combined...
The reactivation of anticancer immunity is a fundamental principle in cancer immunotherapy as evidenced by the use of immune checkpoint inhibitors (ICIs). While treatment with the ICIs is shown to have remarkable and durable therapeutic effects in the responders, the low objective response rate (<40%) continues to be a major problem. Since myeloid‐derived suppressor cells (MDSCs), heterogenous...
3D Multi‐Faceted Tumor Models
In article number 2205904, Bee Luan Khoo and co‐workers present a novel microfluidic tumor model, TAMPIEB, which integrates tumor‐associated macrophages (TAMs) and bladder cancer cells to investigate the influence of bacterial distribution on immunomodulation in the tumor microenvironment in vivo. This research represents the first successful demonstration that biofilm‐induced...
Components of the tumor microenvironment (TME), such as tumor‐associated macrophages (TAMs), influence tumor progression. The specific polarization and phenotypic transition of TAMs in the tumor microenvironment lead to two‐pronged impacts that can promote or hinder cancer development and treatment. Here, a novel microfluidic multi‐faceted bladder tumor model (TAMPIEB) is developed incorporating TAMs...
Energy band structure of inorganic nano‐sonosensitizers is usually optimized by surface decoration with noble metals or metal oxide semiconductors, aiming to enhance interfacial charge transfer, augment spin‐flip and promote radical generation. To avoid potential biohazards of metallic elements, herein, metal‐free graphitic carbon nitride quantum dots (g‐C3N4 QDs) are anchored onto hollow mesoporous...
The phototheranostics in the second near‐infrared window (NIR‐II) have proven to be promising for the precise cancer theranostics. However, the non‐responsive and “always on” imaging mode lacks the selectivity, leading to the poor diagnosis specificity. Herein, a tumor microenvironment (TME) activated NIR‐II phototheranostic nanoplatform (Ag2S‐Fe(III)‐DBZ Pdots, AFD NPs) is designed based on the principle...
Enzyme‐instructed self‐assembly of bioactive molecules into nanobundles inside cells is conceived to potentially disrupt plasma membrane and subcellular structure. Herein, an alkaline phosphatase (ALP)‐activatable hybrid of ICG‐CF4KYp is facilely synthesized by conjugating photosensitizer indocyanine green (ICG) with CF4KYp peptide via classical Michael addition reaction. ALP‐induced dephosphorylation...
Canonical phototherapeutics have several limitations, including a lack of tumor selectivity, nondiscriminatory phototoxicity, and tumor hypoxia aggravation. The tumor microenvironment (TME) is characterized by hypoxia, acidic pH, and high levels of H2O2, GSH, and proteases. To overcome the shortcomings of canonical phototherapy and achieve optimal theranostic effects with minimal side effects, unique...
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