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Significant progress is achieved for the utilization of graphene quantum dots as enzyme mimics in various biomedical fields recently. Although promising, the biocatalytic performance is far from satisfactory. Here, the rational design and synthesis of specific oxygenated groups enriched graphene quantum dots (o‐GQDs) via a facile oxidation reflux route is reported. These well‐prepared o‐GQDs with...
It has been widely reported that “naked” gold nanoparticles (Au NPs) without protectors have glucose oxidase (GOx)‐like activity, and the use of protectors can inhibit the GOx‐like activity. Here, “non‐naked” Au NPs with GOx‐like activity are synthesized by using protein as protector. Although “naked” Au NPs have peroxidase‐like activity and GOx‐like activity, the optimal pH ranges of the both activities...
In biological systems, nature enzymes work together in an efficacious way to undertake metabolic processes by confining cooperating enzymes within compartments. In article number 1804987, Yan Liu, Rong Guo, and co‐workers develop a facile and effective self‐assembly strategy for constructing an integrated artificial enzyme cascade platform based on protein‐BiPt nanochain@graphene oxide nanohybrid...
Nanozymes provide new opportunities for facilitating next generation artificial enzyme cascade platforms. However, the fabrication of high‐performance integrated artificial enzyme cascade (IAEC) bioplatforms based on nanozymes remains a great challenge. A facile and effective self‐assembly strategy for constructing an IAEC system based on an inorganic/protein hybrid nanozyme, β‐casein‐BiPt nanochain@GO...
Single‐atom catalysts (SACs) have attracted extensive attention in the catalysis field because of their remarkable catalytic activity, gratifying stability, excellent selectivity, and 100% atom utilization. With atomically dispersed metal active sites, Fe‐N‐C SACs can mimic oxidase by activating O2 into reactive oxygen species, O2−• radicals. Taking advantages of this property, single‐atom nanozymes...
The modernized use of nucleic acid (NA) sequences to drive nanostructure self‐assembly has given rise to a new class of designed nanomaterials with controllable plasmonic functionalities for broad surface‐enhanced Raman scattering (SERS)‐based bioanalysis applications. Herein, dual usage of microRNAs (miRNAs) as both valuable cancer biomarkers and direct self‐assembly triggers is identified and capitalized...
Nanozymes with unique enzyme‐like catalytic properties and versatile functionalities are particularly attractive for the treatment of bacterial infections, especially for combating drug‐resistant bacteria. However, inherently low catalytic activity significantly limits their antibacterial performance. Herein, a new near‐infrared II (NIR‐II) light responsive nanozyme (Cu2MoS4 nanoplates, CMS NPs) is...
Nanozyme has emerged as a versatile nanocatalyst yet is constrained with limited catalytic efficiency and specificity for various biomedical applications. Herein, by elaborately integrating the recognition/transduction carbon dots (CDs) with platinum nanoparticles (PtNPs), an exquisite CDs@PtNPs (CPP) nanoflare is engineered as an efficient and substrate‐specific peroxidase‐mimicking nanozyme for...
Chemical transformation in cellular environment is critical for regulating biological processes and metabolic pathways. Harnessing biocatalytic cascades to produce chemicals of interest has become a research focus to benefit industrial and pharmaceutic areas. Nanoreactors, which can act as artificial cell‐like devices to organize cascade reactions, have been recently proposed for potential therapeutic...
Nanozymes are fundamentally interesting catalysts that are investigated as alternatives to fragile protein‐enzymes for applications in biotechnology, for prodrug activation, and use in biomedicine, as well as the catalysts that contributed to the Origin of Life. However, until now, nanozymes mostly have been documented to exhibit activity as red/ox catalysts, whereas examples of activity outside this...
Nanozymes with high catalytic activity and great stability have attracted increasing interests as the promising alternative to natural enzymes for applications in various fields. In this study, a new type of highly efficient peroxidase‐like nanozymes based on FeWOX nanosheets (NSs) synthesized by a thermal‐decomposition method is reported. Owing to the sheet‐structure with maximized utilization of...
Nanoparticles have been widely used in detection and killing of bacteria; however, targeting bacteria is still challenging. Delicate design of nanoparticles is required for simultaneous targeting, detection, and therapeutic functions. Here the use of Au/MnFe2O4 (Au/MFO) Janus nanoparticles to target Gram‐positive bacteria via metabolic labeling is reported and realize integrated self‐reporting and...
Dual phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has shown a great prospect in cancer treatment. However, its therapeutic effect is restricted by the depth of light penetration in tissue and tumor hypoxia environment. Herein, inspired by the specific response of nanozymes to the tumor microenvironment (TME), a simple and versatile nanozyme‐mediated synergistic...
A photoresponsive nanozyme with peroxidase‐ and catalase‐like activities, photodynamic and photothermal properties is designed in article number 2007090 by Huiyu Liu and co‐workers. Its synergistic catalytic therapy and dual phototherapy show unique advantages for tumor treatment.
Nanoassemblies based on self‐assembly of biological building blocks are promising in mimicking the nanostructures, properties, and functionalities of natural enzymes. However, it remains a challenge to design of biomimetic nanozymes with tunable nanostructures and enhanced catalytic activities starting from simple biomolecules. Herein, the construction of nanoassemblies through coassembly of an amphiphilic...
Biocatalysts immobilization with nanomaterials has promoted the development of biocatalysis significantly and made it an indispensable part of catalysis industries nowadays. Metal–organic frameworks (MOFs), constructed from organic linkers and metal ions or clusters, have raised significant interests for biocatalysts immobilization in recent years. The diversity of building units, molecular‐scale...
Though nanozymes are successfully applied in various areas, the increasing demands facilitate the exploitation of nanozymes possessing higher activity and more functions. Natural enzyme‐linked receptors (ELRs) are critical components for signal transductions in vivo by expressing activity variations after binding with ligands. Inspired by this, the defect‐engineered carbon nitrides (DCN) are reported...
Nanozymes have offered remarkable advantages over natural enzymes and found widespread applications including biosensors, immunoassays, nanomedicines, and environmental remediation. Oxidation of o‐phenylenediamine (OPD) by nanozymes has been listed as a standard protocol for determining nanozyme activities. Given the complexity of OPD oxidation processes, however, the mechanism of nanozyme‐catalyzed...
Nanozyme‐based chemodynamic therapy (CDT) for fighting bacterial infections faces several major obstacles including low hydrogen peroxide (H2O2) level, over‐expressed glutathione (GSH) in infected sites, and inevitable damage to healthy tissue with abundant nonlocalized nanozymes. Herein, a smart ultrasmall Fe3O4‐decorated polydopamine (PDA/Fe3O4) hybrid nanozyme is demonstrated that continuously...
Ceria nanoparticles (NPs) are widely reported to scavenge nitric oxide (NO) radicals. This study reveals evidence that an opposite effect of ceria NPs exists, that is, to induce NO generation. Herein, S‐nitrosoglutathione (GSNO), one of the most biologically abundant NO donors, is catalytically decomposed by ceria NPs to produce NO. Ceria NPs maintain a high NO release recovery rate and retain their...
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