Polyethylene glycol (PEG) films with PEG diacrylate (PEGd) have been prepared comprising a Ti alkoxyde that turns the film into a nano‐hybrid with potential interest for the production of controlled bioadhesive surfaces. Precursor sols were cast onto Si (100) surfaces, producing conformed films. Modification of such surfaces was performed by exposing the surfaces to UV light (365 nm) at different exposure times. The surface of the hybrid films was characterized by using atomic force microscopy and X‐ray photoelectron spectroscopy. It is concluded that the UV exposure induces a densification of the film and an in‐film coalescence of the titania nanoparticles. This had a direct effect on the wettability of the films as determined by water contact angle measurements. Both as‐cast and UV modified surfaces were proved to be biocompatible as deduced from nuclear immunocytochemistry proliferation assays. Copyright © 2010 John Wiley & Sons, Ltd.