This paper is concerned with the frequency‐dependent fault detection scheme for networked systems under uniform quantization and try‐once‐discard protocol scheduling. By considering the communication constraint and the data node scheduling, a switched system is firstly modeled to characterize the dynamic features of the whole system. The switching function of the derived system is determined by the try‐once‐discard protocol. For this class of system, a sufficient condition to ensure the exponentially ultimately boundedness is established. With the aid of some novel analysis processes, sufficient conditions to characterize the desired finite frequency performances, which transform the frequency‐domain restrictions into time‐domain conditions, are subsequently developed. Then, the fault detection filters corresponding to the transmission nodes are synthesized by solving an optimization problem. Finally, an application to VTOL aircraft is presented to illustrate the effectiveness of the proposed fault detection strategy.