In this paper, the control problem of linear systems with periodic sampling period subject to actuator saturation is considered via delta operator approach. Using periodic Lyapunov function, sufficient conditions of local stabilization for periodic sampling systems are given. By solving an optimization problem, we derive the periodic feedback control laws and the estimate of the domain of attraction. As the saturation function sat(·) belongs to the sector [0,1], sufficient conditions are derived by constructing saturation‐dependent Lyapunov functions to ensure that the periodic sampling system is globally asymptotically stable. A numerical example is given to illustrate the theoretical results proposed in this paper. Copyright © 2014 John Wiley & Sons, Ltd.