Fictitious hydrogen atoms H*A of variable nuclear charge 0.5 ≤ ZA ≤ 2 (and thus of variable electronegativity) are used to study the intrinsic dependency of chemical bonding on electronegativity. Dissociation energy and equilibrium distance are reported for symmetrical 1‐, 2‐ and 3‐electron H*AH*A systems and 2‐electron dissymmetrical H*A‐H ones. Dealing with symmetrical systems, the strongest two‐electron bonds are found for ZA ≈ 1.2. Oneelectron and three‐electron strongest bonds occur respectively with low (ca. 0.7) and high (ca. 1.7) ZA values and can become stronger than the corresponding 2‐electron system. Comparison with data on real systems leads to conclude that electronegativity is a prevailing atomic property in the control of the dissociation energy of symmetrical 1‐, 2‐ and 3‐electron bonds. A simplified mathematical model at Hartree‐Fock or Heitler‐London level with a minimal basis set reproduces these trends semi‐quantitatively and provides the overall shape of the dissociation curves. Finally some points are qualitatively discussed from MO analysis, which emphasize the dependence of the bonding/antibonding properties on the nucleus charge ZA and their occupancy number. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011