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Candida albicans is the principal opportunistic fungal pathogen in nosocomial settings and resistance to antifungal drugs is on the rise. Antimicrobial peptides from natural sources are promising novel therapeutics against C. albicans. OsDef2 defensin was previously found to be active against only Gram‐positive bacteria, whereas derived fragments Os and its cysteine‐free analogue, Os‐C, are active...
Peptide‐bound methionine may transfer oxidative damage from the thioether side chain to the peptide backbone, catalyzing decomposition in general and α‐amidation in particular. In the present study, we focused on the reactivity and reaction pathways of peptides. We synthesized model peptides comprising methionine or not and investigated their overall tendency towards decomposition and formation of...
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