There remains a lack of a clear overarching policy framework for decision‐making in pest control programmes. In comparison, ethical principles have been extensively developed for scientific procedures, such as those underlying the UK's Animals (Scientific Procedures) Act 1986. This paper assesses the extent to which the principles and methodology underlying the act and secondary guidance could be used to provide principles of rodent management. Useful principles include that any programme has a legitimate purpose; that methods are used only if the harms are outweighed by the benefits; that harms are minimised by refinement, replacement and reduction and that there is personal responsibility. The usefulness and implications for pest control of each principle and the overall approach are discussed. Copyright © 2009 Society of Chemical Industry