Seven rounds of CAPRI predictions with a total of 14 targets were held in the period June 2007–November 2009. In addition to protease/inhibitor complexes and complexes with G‐proteins, some of the targets displayed novel features presenting new challenges to the predictors: a complex with RNA, a leucine zipper to be built abinitio, and a human‐designed protein. Nine targets were unbound or required model building; the other five had a bound component. Thirteen were assessed, and the results show that the predictor and scorer groups submitted two‐ or three‐star (medium or high quality) models for eight of them, one‐star (acceptable) models for three but failed on the unbound RNA complex and another unbound target. Proteins 2010. © 2010 Wiley‐Liss, Inc.