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BACKGROUNDTwo clinical trials have shown that users of 5α‐reductase inhibitors finasteride and dutasteride (5‐ARIs) have reduced overall prostate cancer risk, while the proportion of high‐grade tumors is increased. We studied tumor characteristics, risk of biochemical recurrence and mortality after radical prostatectomy in 5‐ARI and alpha‐blocker users.
METHODSThe study cohort consisted of 1,315...
BACKGROUNDWe investigated associations between statin use begun before prostate cancer (PCa) diagnosis and PCa recurrence/progression and PCa‐specific mortality (PCSM) in a prospective, population‐based cohort study.
METHODSThe analysis included 1,001 PCa patients diagnosed in 2002–2005 in King County, Washington. Statin use was assessed at the time of diagnosis using a detailed in‐person interview...
BACKGROUNDObservational studies suggest an inverse association between vitamin E and risk of prostate cancer, particularly aggressive tumors. However, three large randomized controlled trials have reported conflicting results. Thus, we examined circulating vitamin E and vitamin E‐related genes in relation to risk of high‐grade prostate cancer and prostate cancer recurrence among men initially diagnosed...
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