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BACKGROUNDTaxanes are the only cytotoxic chemotherapeutic agents proved to prolong the survival in patients with castration‐resistant prostate cancer. However, because of intrinsic and acquired resistances to taxanes, their therapeutical efficiencies are modest, bringing only a few months of survival benefit. Y‐box binding protein‐1 (YB‐1) promotes cancer cell resistance to various anticancer treatments,...
BACKGROUNDPreviously, we have shown that Y‐box binding protein‐1 (YB‐1) regulates androgen receptor (AR) expression and contributes to castration resistance. However, the mechanism of YB‐1 activation remains unknown. In this study, we aimed to elucidate the mechanism and role of YB‐1 activation in relation to castration resistance as well as enzalutamide resistance, with a view to developing a novel...
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