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Cellular communication relies on signaling circuits whose statuses are mainly modulated by soluble biomolecules such as carbohydrates, lipids, proteins, and metabolites as well as extracellular vesicles (EVs). Therefore, the active secretion of such biomolecules is critical for both cell homeostasis and proper pathophysiological responses in a timely fashion. In this context, proteins are among the...
The cancer cell secretome comprises a treasure‐trove for biomarkers since it reflects cross‐talk between tumor cells and their surrounding environment with high detectability in biofluids. In this study, we evaluated six secretome sample processing workflows coupled to single‐shot mass spectrometry: (1) Protein concentration by ultrafiltration with a molecular weight cut‐off (MWCO) filter and sample...