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This is the first differential expression proteomics study on a human syngeneic cellular in vitro progression model of the colorectal adenoma‐to‐carcinoma sequence, the anchorage‐dependent non‐tumorigenic adenoma derived cell line AA/C1 and the derived anchorage‐independent and tumorigenic carcinoma cell line AA/C1/SB10C. The study is based on quantitative 2‐DE and is complemented by Western blot...
Progression to metastasis is the critical point in colorectal cancer (CRC) survival. However, the proteome associated to CRC metastasis is very poorly understood at the moment. In this study, we used stable isotope labeling by amino acids in cell culture to compare two CRC cell lines: KM12C and KM12SM, representing poorly versus highly metastatic potential, to find and quantify the differences in...
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