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Most proteins function by forming complexes within a dynamic interconnected network that underlies various biological mechanisms. To systematically investigate such interactomes, high‐throughput techniques, including CF‐MS, have been developed to capture, identify, and quantify protein‐protein interactions (PPIs) on a large scale. Compared to other techniques, CF‐MS allows the global identification...
Proteins play an essential role in the vital biological processes governing cellular functions. Most proteins function as members of macromolecular machines, with the network of interacting proteins revealing the molecular mechanisms driving the formation of these complexes. Profiling the physiology‐driven remodeling of these interactions within different contexts constitutes a crucial component to...
Trans‐activation response DNA binding protein of 43 kDa (TDP‐43) regulates a great variety of cellular processes in the nucleus and cytosol. In addition, a defined subset of neurodegenerative diseases is characterized by nuclear depletion of TDP‐43 as well as cytosolic mislocalization and aggregation. To perform its diverse functions TDP‐43 can associate with different ribonucleoprotein complexes...