DOI: 10.1002/pmic.201900057
Oligodendrocytes, the myelinating cells of the central nervous system, are generated by differentiation of oligodendrocyte precursor cells through mechanisms which are only incompletely understood. This process is pathogenetically relevant for several diseases affecting myelin, and a better understanding holds the promise to develop novel therapeutic approaches. In article number 1900057, Schoor et al. investigate oligodendrocyte precursor cell differentiation by quantitative proteomics. Their results identify proteins, which are regulated with distinct patterns during the transition from precursor cells to oligodendrocytes, and are therefore potentially involved in basic cellular functions of the individual cell types and their differentiation.