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Highly malignant osteosarcoma (HMO) is the most frequent malignant bone tumor preferentially occurring in adolescents and children with a second more flat peak in patients over the age of 60. The younger patients benefit from combined neoadjuvant chemotherapy with 65–70% 5‐year survival rate. In patients with metastatic HMO the 5‐year survival rate is consistently poor with approximately 30%. In the...
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