Artificial intelligence (AI) has become increasingly studied and implemented in some pathology departments; but how might AI models help change medicine? While technology leaders are calling for a pause on developing AI systems until there is greater confidence “that their effects will be positive and their risks will be manageable,” (Pause Giant AI Experiments: An Open Letter. March 22, 2023. https://futureoflife.org/open-letter/pause-giant-ai-experiments/) could breakthrough innovations in AI make medicine and physicians better? (There's One Hard Question My Fellow Doctors and I Will Need to Answer Soon. July 6, 2023. https://www.nytimes.com/2023/07/06/opinion/artificial-intelligence-medicine-healthcare.html) This discussion will provide an overview of AI, its current role in pathology practice, what pathologists need to know, and what the College of American Pathologists is doing for pathologists in this area.