Introduction
A new solid‐phase microextraction fibre is fabricated through polymerisation of molecularly imprinted polymer on the surface of a layered double hydroxide framework that has been fabricated via the in situ synthesis on a non‐porous anodic aluminium oxide/aluminium wire as both the substrate and the aluminium source.
Objective
The synthesized SPME fiber was performed to analyze trace digoxin in real samples.
Material and method
A one‐at‐a‐time optimization strategy was applied for optimizing the important extraction parameters such as extraction solvent, extraction time, stirring rate, pH, ionic strength, and desorption time.
Result
Aluminum surface before and after anodizing and LDH structure reveal that anodizing and preparation LDH increases the surface area and adsorption capacity of aluminum wire.
Conclusion
Under optimum conditions, the repeatability for one fibre (n = 3), expressed as relative standard deviation (RSD %), was 5.2%.