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BackgroundPoor outcome in Stage 4 neuroblastoma may be improved with increased dose intensity of therapy. We investigated the feasibility of sequential collection and infusion of peripheral blood stem cells (PBSCs) as hematopoietic support for non‐myeloablative dose intensive induction chemotherapy given every 21–28 days.
MethodsTwenty‐two children with Stage 4 neuroblastoma (≥1 year of age) received...
Neonatal neuroblastoma may require chemotherapy either due to mass effect or unfavourable cytogenetics. This case focuses on using pharmacokinetic (PK) guided chemotherapy to treat neonatal neuroblastoma. A newborn baby was noted to have left leg immobility. Imaging showed a retroperitoneal tumour with spinal canal extension causing spinal cord compression. PK‐guided carboplatin was given after conventionally...
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