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In recent years, undifferentiated small round cell sarcomas (USRCSs) have been divided into a variety of new, rare, sarcoma subtypes, including the group of Ewing‐like sarcomas, which have the morphological appearance of Ewing sarcomas, but carry CIC–DUX4, BCOR–CCNB3 and other gene fusions different from the classic EWSR1–ETS gene fusion. Using high‐throughput RNA‐sequencing (RNA‐seq) analyses, we...
Developmental transcription programs are epigenetically regulated by multi‐protein complexes, including the menin‐ and MLL‐containing trithorax (TrxG) complexes, which promote gene transcription by depositing the H3K4me3 activating mark at target gene promoters. We recently reported that in Ewing sarcoma, MLL1 (lysine methyltransferase 2A, KMT2A) and menin are overexpressed and function as oncogenes...
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