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Activation of the alternative complement pathway is an initiating event in the pathology of age‐related macular degeneration (AMD). Unchecked complement activation leads to the formation of a pro‐lytic pore, the membrane attack complex (MAC). MAC deposition is observed on the choriocapillaris of AMD patients and likely causes lysis of choroidal endothelial cells (CECs). Complement factor H (FH, encoded...
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