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It is currently hoped that deaths from extra‐uterine high‐grade serous cancer (HGSC) will be reduced via opportunistic salpingectomy in healthy women. Accumulated data implicate the fimbria as a site of origin and descriptive molecular pathology and experimental evidence strongly support a serous carcinogenic sequence in the Fallopian tube. Both direct and indirect (‘surrogate’) precursors suggest...
The oviducts contain high‐grade serous cancer (HGSC) precursors (serous tubal intraepithelial neoplasia or STINs), which are γ‐H2AXp‐ and TP53 mutation‐positive. Although they express wild‐type p53, secretory cell outgrowths (SCOUTs) are associated with older age and serous cancer; moreover, both STINs and SCOUTs share a loss of PAX2 expression (PAX2n). We evaluated PAX2 expression in proliferating...
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