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BackgroundEvidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction. Topical combinations of α2‐adrenergic receptor agonists or nitric oxide donors with phosphodiesterase or phosphatidic acid inhibitors formulated to treat microvascular dysfunction have been shown to reduce allodynia in a rat model of CRPS‐I. Driven by these findings, we assessed...
IntroductionKetamine is a commonly used analgesic agent in the management of both acute and chronic pain. While dose‐dependent side effects are well described, allergy to ketamine is extremely rare.
CaseA 41‐year‐old woman with chronic pelvic pain and previous ketamine exposure developed a widespread urticarial rash and mild perioral edema following the initiation of a ketamine infusion. The infusion...
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