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Objective
The aim of this study was to examine cross‐sectional associations between objectively measured sedentary time and magnetic resonance imaging (MRI)‐assessed adiposity in a population at high risk for type 2 diabetes (T2DM) and to determine whether associations are modified by the recommended levels of moderate‐to‐vigorous physical activity (MVPA).
Methods
Sedentary time and MVPA were measured...
Objective
This study aimed to conduct a comprehensive assessment of the presence, severity, and sociodemographic correlates of weight bias internalization (WBI) across three distinct samples of US adults.
Methods
Levels of WBI were compared in (1) a sample of adults with obesity and heightened risk of weight stigma (N = 456), (2) an online community sample (N = 519), and (3) a national online panel...
Objective
This study examined whether metabolic health status is associated with risk of cancer mortality and whether this varies by body mass index (BMI) category.
Methods
A prospective study of 22,514 participants from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was performed. Metabolically unhealthy status was defined as having three or more of the following:...
Objective
ACTION (Awareness, Care, and Treatment in Obesity maNagement) examined obesity‐related perceptions, attitudes, and behaviors among people with obesity (PwO), health care providers (HCPs), and employer representatives (ERs).
Methods
A total of 3,008 adult PwO (BMI ≥ 30 by self‐reported height and weight), 606 HCPs, and 153 ERs completed surveys in a cross‐sectional design.
Results
Despite...
Objective
The objective of this study was to compare patterns of objectively measured moderate‐to‐vigorous physical activity (MVPA, ≥ 3.00 metabolic equivalents [METs]), light‐intensity physical activity (LPA, 1.50‐2.99 METs), and sedentary behavior (SB, < 1.50 METs) in successful weight loss maintainers (WLMs), normal weight controls (NC), and controls with overweight/obesity (OC).
Methods...
Objective
This study aimed to evaluate the real‐world safety and effectiveness of the LAP‐BAND (Apollo Endosurgery Inc., Austin, Texas) adjustable gastric banding system (LBS) for 5 years following implantation.
Methods
This prospective, longitudinal, phase 4, multicenter study involved 652 patients who had implantation of the LBS system. The primary outcome was the percentage of subjects who had...
Objective
This study aimed to evaluate the association between prepregnancy body mass index (BMI), gestational weight gain (GWG), and cesarean delivery in Hispanics.
Methods
We examined these associations among 1,215 participants in Proyecto Buena Salud, a prospective cohort of Hispanic women studied from 2006 to 2011. Prepregnancy BMI, GWG, and the mode of delivery were abstracted from medical...
Objective
Sodium glucose cotransporter 2 (SGLT2) inhibitors may induce urinary glucose excretion via the inhibition of renal glucose reabsorption, improve glycemic control, and lower body weight. The aim of this meta‐analysis was to evaluate weight changes in patients who received different dosages of SGLT2 inhibitors.
Methods
Overall, 55 placebo‐controlled trials were included.
Results
The results...
Objective
Human brown adipose tissue (BAT) activity decreases with age and obesity. In addition to uncoupling protein 1 (UCP1), several genetic markers of BAT in humans have been published. However, the link between human BAT activity and genetic markers has been inadequately explored.
Methods
White adipose tissue (WAT) and BAT biopsies were obtained from 16 patients undergoing deep neck surgery...
Objective
The objective of the present study was to examine whether wild rodents exhibit diverse obesity susceptibility and what factors predispose subjects to this divergence in response to a high‐fat diet (HFD).
Methods
Sixty male and female Brandt's voles (Lasiopodomys brandtii) were fed an HFD for 8 weeks, and the upper (obesity prone [OP]) and lower (obesity resistant [OR]) one‐third for mass...
Objective
This study sought to understand how the dietary source of carbohydrates, either high‐fructose corn syrup (HFCS) or complex carbohydrates, affects energy expenditure (EE) measures, appetitive sensations, and hormones during 24 hours of overfeeding.
Methods
Seventeen healthy participants with normal glucose regulation had 24‐hour EE measures and fasting blood and 24‐hour urine collection...
Objective
This study aimed to estimate treatment costs attributable to overweight and obesity in patients with diabetes who were less than 65 years of age in the United States.
Methods
This study used data from the Medical Expenditure Panel Survey from 2001 to 2013. Patients with diabetes were identified by using the International Classification of Diseases, Ninth Revision, Clinical Modification...
Objective
Equivocal findings have been reported on the association between maternal depression and children's growth, possibly because of the limited attention to its disproportionate impact by child sex. The relationship between the timing of maternal depression and children's growth was assessed in a population‐based prospective birth cohort, with particular attention to sex differences.
Methods...
Objective
This study aimed to compare cortex thickness and neuronal cell density in postmortem brain tissue from people with overweight or obesity and normal weight.
Methods
The cortex thickness and neuron density of eight donors with overweight or obesity (mean = 31.6 kg/m2; SD = 4.35; n = 8; 6 male) and eight donors with normal weight (mean = 21.8 kg/m2; SD = 1.5; n = 8; 5 male) were compared...
Objective
Abnormal fat metabolism is a major disorder in adults who were small for gestational age (SGA). Peroxisome prolferator‐activated receptor (PPARγ) participates in adipocyte differentiation and the regulation of lipid metabolism. This study explored the role of PPARγ in the regulation of fat catch‐up growth (CUG) and the lipid metabolism of SGA individuals.
Methods
The CUG‐SGA rats were...
Objective
This study aimed to assess the association between adverse childhood experiences (ACEs) and adiposity in adolescents from two cohorts in different socioeconomic contexts.
Methods
Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) and the 1993 Pelotas Cohort (Brazil) were used. Six ACEs were assessed in both cohorts up to age 15. At 15 years, body mass...
Objective
The association between socioeconomic status (SES) and body mass index (BMI) in middle‐income countries is mixed. Heterogeneity in SES indicators used could explain some differences. This study aimed to identify SES indicators consistently associated with BMI in Mexican adults in 2006, 2012, and 2016.
Methods
Data were obtained from the Mexican National Health and Nutrition Surveys of...
Objective
To examine specific molecular mechanisms involved in modulating hepatic lipogenesis and mitochondria biogenesis signals by Lithospermum erythrorhizon (gromwell) root extract.
Methods
Stable cell lines with luciferase reporter constructs were generated to examine sterol regulatory element binding protein 1c (SREBP1c) and peroxisome proliferator‐activated receptor gamma, coactivator 1 (PGC1)...
Objective
The objective of this study was to test whether behavioral weight loss (BWL) intervention decreases headaches in women with comorbid migraine and overweight or obesity.
Methods
This randomized, single‐blind trial allocated women 18 to 50 years old with 4 to 20 migraine days per month and a BMI = 25.0‐49.9 kg/m2 to 16 weeks of BWL (n = 54), which targeted exercise and eating behaviors...
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