This study deals with obtaining numerical solutions of two‐dimensional (2D) fractional cable equation in neuronal dynamics by using a recently introduced meshless method. In solution process at first stage, time derivatives that are appeared in the considered problem are discretized by using finite difference method. Then a meshless method based on hybridization of Gaussian and cubic kernels is developed in local fashion. The problem is solved both on regular and irregular domians. L∞ and RMS error norms are calculated and compared with other numerical methods in literature as well as exact solutions. Also, obtained condition numbers are monitored. Numerical simulations show that local hybrid kernel meshless method is a thriving method for solving 2D fractional cable equation on regular and irregular domians.