This chapter discusses policy implications and applications of the comprehensive credit assessment framework (CCAF) to crisis intervention and prevention. It also discusses the key elements for crisis intervention while addressing the concerns about helping those who are genuinely in need. To prevent future financial crises a new framework is proposed that can better address the key issues, including improving transparency, financial literacy, and monitoring both risk and greed. The chapter describes how CCAF can help achieve the above goals and, in particular, how to build an effective loan monitoring system from the regulator's perspective that also benefits borrowers, lenders, and investors. Examples are used to illustrate potential applications to facilitate crisis intervention and prevention.