Mobile devices in education present a distinct opportunity to reach all students. Where certain populations might have been marginalized by past technologies or traditional classroom structures, mobile technology offers a new way to personalize and make learning accessible for those with special needs. In this chapter, we'll discuss the functions that set Apple's iOS apart as the market leader for accessibility and how this impacts two specific populations: those on the autism spectrum and students with visual impairments. We also present things to consider when making an app to ensure it is accessible to all users. For students with autism, iPads offer a wealth of apps that offer the opportunity to enhance social interaction aptitude, verbal and nonverbal communication skills, and self‐regulation. For users with visual impairment, the ease of adjusting settings on the iPad is a huge benefit, enabling ready usability for users with low or no vision. iPads work seamlessly with many accessories that enhance the experience for the visually impaired, such as refreshable braille displays. This chapter concludes with a discussion about how to develop for maximum usability, to ensure that all educational apps are accessible.