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Since its inception in 1975, the NINDS‐sponsored Anticonvulsant Screening Program at the University of Utah has contributed to the development of several clinically approved antiepileptic drugs (AEDs) for the symptomatic management of epilepsy. The most commonly employed animal models utilized in this programme are the maximal electroshock (MES) model of tonic–clonic epilepsy, originally utilized...
This chapter summarizes the basis and clinical use of vagus nerve stimulation (VNS), including new technologies for stimulating the vagus nerve, and provides an overview of trigeminal nerve stimulation (TNS). Vagus nerve stimulation has been investigated in a number of animal models of epilepsy. In most of these studies, stimulation was applied just before or immediately after the onset of a seizure...
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