The use of human embryonic stem cells (hESC) induced pluripotent stem cells (iPSCs), collectively referred as pluripotent stem cells (PSC) for the functional replacement of damaged neurons, in vitro disease modeling, and screening for toxicity studies, is of tremendous relevance to the study of neuroscience. However, the process of coaxing PSC lines to differentiate into neurons is laborious, subjective due to several manual steps, highly variable, and sometimes even non‐reproducible. Well‐adopted methods towards neural induction and differentiation that are highly reproducible with reliability, are critical in order for PSCs to move into the area of translational medicine for use in preclinical and clinical intervention/screening studies for neural diseases.