Mycoses
Early detection and characterisation of a pulmonary focus is a major goal in febrile neutropenic patients. Thus, an intensive interdisciplinary co‐operation between radiologists and haemato‐oncologists on a patient basis, as well as on a department basis is essential to develop a differential diagnosis. The radiologist can contribute much to a differential diagnosis if information about the patient’s...
Representatives of the genus Pseudallescheria (anamorph: Scedosporium) are saprobes and the aetiologic agent of invasive mycosis in humans. After dissemination, the central nervous system (CNS) is one of the most affected organs. Prerequisites for the survival of Pseudallescheria/Scedosporium in the host are the ability to acquire nutrients and to evade the immune attack. The cleavage of complement...
The potential of mMass software search tool with new compound libraries was demonstrated on metabolomics of Scedosporium prolificans, S. apiospermum and Pseudallescheria boydii sensu stricto. Cyclic peptides pseudacyclins, small molecular weight tyroscherin analogues and various lipids were annotated by public software tool (http://www.mmass.org) utilising accurate matrix‐assisted laser desorption/ionisation...
Since the latest taxonomical changes in the genus Scedosporium by Gilgado et al. in 2010, no species‐specific studies on epidemiology and antifungal susceptibility patterns (AFSP) have so far been published. This study aimed to provide qualitative epidemiological data of Scedosporium spp. isolated from cystic fibrosis (CF) patients and immunocompromised patients from Northern Spain. Isolates were...
During the last few decades, Pseudallescheria and Scedosporium infections in humans are noted with increasing frequency. Multi‐drug resistance commonly occurring in this species complex interferes with adequate therapy. Rapid and correct identification of clinical isolates is of paramount significance for optimal treatment in the early stages of infection, while strain typing is necessary for epidemiological...
Prosthetic joint infections (PJI) are rarely due to fungal agents and if so they are mainly caused by Candida strains. This case represents a PJI caused by a multi‐drug resistant Pseudallescheria apiosperma, with poor in vivo response to itraconazole and voriconazole. This case differs also by the way of infection, since the joint infection did not follow a penetrating trauma. In the majority of cases,...
Livia Cristina L. Lopes,
Mariana Ingrid D. da Silva,
Vera Carolina B. Bittencourt,
Rodrigo T. Figueiredo,
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Peptidorhamnomannans (PRMs), rhamnomannans and α‐glucans are especially relevant for the architecture of the Scedosporium/Pseudallescheria boydii cell wall, but many of them are immunologically active, with great potential as regulators of pathogenesis and the immune response of the host. In addition, some of them can be specifically recognised by antibodies from the sera of patients, suggesting that...
The PCR‐RLB (reverse line blot hybridisation) was applied as a molecular technique for the detection of members of Pseudallescheria and Scedosporium from sputum of patients with cystic fibrosis (CF). Fifty‐nine sputum samples were collected from 52 CF patients, which were analysed by culture and PCR‐RLB. Conventional and semi‐selective culture yielded five positive samples, but the PCR‐RLB hybridisation...
Recurrent candidaemia is both a cause and a symptom of deep organ candidiasis or infection of foreign bodies (e.g. central venous line, other indwelling catheter or pacemaker wire) and is associated with significant morbidity and mortality. This case report demonstrates that in the event of pacemaker wire infection with Candida and when it is not possible to remove the infected pacemaker wire, treatment...
Fusarium species are actually the second most common pathogenic mould in immunocompromised patients, and it is difficult to treat such fusarial infections with current antifungal agents. We report the case of a 53‐year‐old woman with Philadelphia‐positive acute lymphoblastic leukaemia. During induction chemotherapy with febrile neutropenia, she developed a disseminated fusariosis, with persistent...