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Background
Cyberlindnera fabianii has rarely been reported as a human pathogen. Here, we describe an outbreak of C. fabianii fungaemia involving 10 preterm neonates during a seven‐month period in Kuwait and review the published reports.
Methods
Blood cultures were processed, and yeast isolates were initially identified by ID 32 C and/or VITEK 2. Molecular identification was done by PCR sequencing...
Background
Current guidelines recommend echinocandins as first‐line therapy for candidemia. However, several non‐Candida yeast are non‐susceptible to echinocandins (echinocandin non‐susceptible yeast, ENSY), including Cryptococcus, Geotrichum, Malassezia, Pseudozyma, Rhodotorula, Saprochaete, Sporobolomyces and Trichosporon. In laboratories that are not equipped with rapid diagnostic tools, it often...
Background
Patients with extensive burns are at risk of developing candidemia.
Objectives
To identify potentially modifiable risk factors and outcomes of candidemia in critically ill burns patients.
Patients and Methods
Retrospective matched cohort study including adult burns patients. Patients who developed candidemia were matched with burns patients with Candida spp colonisation and sepsis...
Candidaemia is the most common clinical presentation of invasive candidiasis and is a major cause of morbidity and mortality. Candiduria is a predictor for candidaemia; however, patient characteristics that are associated with concurrent candidaemia in the setting of candiduria are unclear. Identifying these characteristics could aid in the early detection of systemic disease. We performed a retrospective...
Background
Candida auris, an emerging nosocomial pathogen, exhibits phenotypic variation. Non‐aggregating C. auris isolates display greater biofilm‐forming capacity and virulence than aggregate‐forming isolates. Most of the studies till date have focused on clinical isolates. The biofilm‐forming capacity of colonising isolates remains uninvestigated.
Objectives
The present study aimed to elucidate...
A paradigm shift of candidiasis from Candida albicans to non‐albicans Candida species has fundamentally increased with the advent of C. auris. C. auris, despite being a newly emerged multidrug‐resistant fungal pathogen, is associated with severe invasive infections and outbreaks with high mortality rates. Initially reported from Japan in 2009, C. auris have now been found in different countries on...
Geographical variation is observed in invasive candida infection (ICI) and differences between critical care units (CCUs) may contribute. To examine rates, risk factors and individual and unit‐level variation of ICI in UK CCUs. Data from the Fungal Infection Risk Evaluation Study was used to examine individuals admitted to 96 CCUs in the UK; July 2009‐March 2011. Cases were non‐neutropenic individuals...
Background
Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance.
Objectives
Triggered by the emergence of C auris and by increasing antifungal resistance...
Candidemia can complicate major surgical procedures. However, literature data are scanty on this topic. In this study, we evaluated the epidemiology, clinical and microbiologic characteristics and outcome of candidemia in adult patients with recent surgery hospitalised in a single University Hospital in Central Italy from 2010 to 2016. Of the 304 episodes of candidemia, 160 (53%) occurred in surgical...
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