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Objectives
Our study aimed to better understand the different thermal adaptation in Mucor irregularis (M. irregularis) strains under high temperature and the involved virulence‐related genes, and to offer more appropriate explanation for the diverse pathogenicity of M. irregularis in human infections.
Methods
M. irregularis isolates were incubated at 30 and 35°C for Illumina HiSeq technology (RNA‐seq),...
Background
Traditionally, KOH microscopy and fungal culture are the two preferred tests as gold standard for diagnosis of onychomycosis. Recently, other diagnostic methods have been developed to improve the microbiological diagnosis. The EUROArray dermatomycosis kit is a PCR‐based microarray test system for the detection and direct identification of species that are most frequently involved in skin...
Background
To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifestations.
Objectives
To describe the characteristics of mucocutaneous mycosis cases in the PLHIV population...
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease with an increasing prevalence worldwide. The aetiology and pathogenesis of AD have not been fully elucidated. Previous studies have suggested the role of fungi as a triggering factor in the development AD. Here we conducted a systematic review to investigate the skin mycobiome profiles in AD and to address whether there is...
Background and Aims
Fungal infections (FIs) have serious implications, yet understated in cirrhosis. Therefore, we reviewed the epidemiology and trends of FIs among cirrhotics.
Methods
Four electronic databases were searched for full‐text articles describing prevalence of FIs in cirrhosis. Studies from post‐transplant, malignancy and classical‐immuno‐deficiency patients were excluded. A random‐effects...
Candida and Cryptococcus affect millions of people yearly, being responsible for a wide array of clinical presentations, including life‐threatening diseases. Interestingly, most human pathogenic yeasts are not restricted to the clinical setting, as they are also ubiquitous in the environment. Recent studies raise concern regarding the potential impact of agricultural use of azoles on resistance to...
Background
Along with COVID‐19 pandemic, India has faced an outbreak of COVID‐19–associated mucormycosis (CAM). Due to restricted availability of amphotericin B during this outbreak, clinicians were forced to use posaconazole or isavuconazole preparations as first‐line or alternate therapy in many patients. We planned an early monitoring of posaconazole trough level while using delayed release (DR)...
Background
Candida auris is an emerging, potentially multidrug‐resistant pathogen that exhibits clade‐specific resistance to fluconazole and also develops resistance to echinocandins and amphotericin B easily. This study analysed 49 C auris isolates for alterations in hotspot‐1 and hotspot‐2 of FKS1 for the detection of mutations conferring reduced susceptibility to echinocandins.
Methods
C auris...
Background
Paracoccidioidomycosis, caused by fungi of the Paracoccidioides genus, is one of the most important endemic mycoses in Brazil. The disease is not of mandatory reporting in the country; however, some Brazilian states, such as Paraná, have included it on their local lists of public health‐reportable diseases.
Objective
Describe the epidemiology of the positive paracoccidioidomycosis cases...
The landscape of fungal endocarditis (FE) has constantly been evolving in the last few decades. Despite the advancement in diagnostic methods and the introduction of newer antifungals, mortality remains high in FE. This systematic review aimed to evaluate the epidemiology, clinical features, diagnostic and therapeutic interventions in patients with FE. We also aim to examine the aforementioned factors...
Background
Mucormycosis is a worldwide angio‐invasive fungal infection that is associated with high morbidity and mortality. A few European studies have focused on the epidemiology.
Methodology
A retrospective longitudinal descriptive study was performed with inpatients diagnosed with mucormycosis (ICD‐9‐CM, code 117.7, cases 1997‐2015; and ICD‐10, code B46, cases 2016‐2018; along with length of...
Objectives
(1) To describe the incidence, clinical characteristics, treatment and outcome of Aspergillus Endocarditis (AE) in a nationwide multicentric cohort (GAMES). (2) To compare the AE cases of the GAMES cohort, with the AE cases reported in the literature since 2010. (3) To identify variables related to mortality.
Methods
We recruited 10 AE cases included in the GAMES cohort (January 2008‐December...
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