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Purpose
We propose a quantitative technique to assess solute uptake into the brain parenchyma based on dynamic contrast‐enhanced MRI (DCE‐MRI). With this approach, a small molecular weight paramagnetic contrast agent (Gd‐DOTA) is infused in the cerebral spinal fluid (CSF) and whole brain gadolinium concentration maps are derived.
Methods
We implemented a 3D variable flip angle spoiled gradient...
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