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ObjectiveThere is a debate if the [NO] required to influence vascular smooth muscle is below 50 nM or much higher. Electrodes with 30 μm and larger diameter report [NO] below 50 nM, whereas those with diameters of <10–12 μm report hundreds of nM. This study examined how size of electrodes influenced [NO] measurement due to NO consumption and unstirred layer issues.
MethodsElectrodes were 2 mm...
ObjectiveWe studied the effects of S1P on the diameter and spontaneous contraction of murine iliac collecting lymph vessels.
MethodsThe isolated lymph vessel was cannulated with two glass micropipettes and then pressurized to 4 cmH2O at the intraluminal pressure. The changes in lymph vessel diameter were measured using a custom‐made diameter‐detection device. Immunohistochemical studies were also...
ObjectiveThe present study was designed to evaluate whether CP was beneficial in alleviating myocardial fibrosis following I/R injury.
MethodsSprague–Dawley rats were subjected to 30 minutes occlusion of the LADCA, followed by reperfusion. CP (0.4 or 0.8 g/kg) was daily administered starting from three hour after reperfusion until day 6. Coronary venular diameter, RBC velocity, albumin leakage, MBF,...
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