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BackgroundWe aimed to determine if peripheral or central inflammatory cytokines are altered in healthy subjects carrying a leucine‐rich repeat kinase 2 (LRRK2) G2019S mutation, and thus genetically at risk of Parkinson's disease (PD). We also aimed to identify differences in inflammatory cytokines between LRRK2 G2019S‐associated and idiopathic PD once the disease manifests.
MethodsParticipants were...
BackgroundMutations in the leucine‐rich repeat kinase 2 (LRRK2) gene are the most common cause of inherited Parkinson's disease (PD). Nonmanifesting carriers of LRRK2 mutations are at high risk for developing PD. Information available on cerebrospinal fluid (CSF) biomarkers in LRRK2 carriers remains preliminary.
ObjectivesTo measure CSF levels of α‐synuclein, β amyloid1‐42, total‐tau, and phospho‐tau...
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