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Gastrointestinal symptoms are evident in all stages of Parkinson's disease (PD). Most of the gastrointestinal abnormalities associated with PD are attributable to impaired motility. At the level of the stomach, this results in delayed gastric emptying. The etiology of delayed gastric emptying in PD is probably multifactorial but is at least partly related to Lewy pathology in the enteric nervous system...
BackgroundThe objective of this work was to perform an open trial of the effects of nizatidine (NZT), a selective histamine H2‐receptor antagonist and a cholinomimetic, on gastroparesis in Parkinson's disease (PD) patients, using objective parameters given by a gastric emptying study using a 13C‐sodium acetate expiration breath test.
MethodsTwenty patients with PD were enrolled in the study. There...
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