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Background
Pathogenic leucine‐rich repeat kinase 2 LRRK2 mutations may increase LRRK2 kinase activity and Rab substrate phosphorylation. Genetic association studies link variation in LRRK2 to idiopathic Parkinson disease (iPD) risk.
Objectives
Through measurements of the LRRK2 kinase substrate pT73‐Rab10 in urinary extracellular vesicles, this study seeks to understand how LRRK2 kinase activity...
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