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Background
The G2385R variant of leucine‐rich repeat kinase 2 (LRRK2) is mainly associated with Parkinson's disease(PD) in Asian populations.
Objective
The aim of this study was to investigate the PD conversion rate and clinical characteristics of LRRK2 G2385R nonmanifesting carriers.
Methods
All participants were from the community‐based longitudinal cohort of Shanghai Ruijin Hospital. The G2385R...
Background
Pathogenic variants in the LRRK2 gene are a common monogenic cause of Parkinson's disease. However, only seven variants have been confirmed to be pathogenic.
Objectives
We identified two novel LRRK2 variants (H230R and A1440P) and performed functional testing.
Methods
We transiently expressed wild‐type, the two new variants, or two known pathogenic mutants (G2019S and R1441G) in HEK‐293...
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