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Parkinson's disease (PD) is pathologically defined by the death of dopaminergic (DA) neurons within the pars compacta of the substantia nigra. To date, the cause of this multifaceted disease remains largely unclear, which may contribute in part to a current lack of disease‐modifying therapies. Recent advances in single‐cell and spatial genomic profiling tools have provided powerful new ways to measure...
Background
Degeneration of the substantia nigra (SN) may contribute to levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD), but the exact characteristics of SN in LID remain unclear.
Objective
To further understand the pathogenesis of patients with PD with LID (PD‐LID), we explored the structural and functional characteristics of SN in PD‐LID using multimodal magnetic resonance imaging...
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