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We previously reported that cycloogenase (COX)‐2‐generated prostaglandin E2 (PGE2) had anti‐apoptotic effects in UVB‐exposed mouse skin that involved EP2‐mediated signaling (Chun et al., Cancer Res. 2007; 67: 2015). Because survivin is a regulator of cell survival, the possible involvement of COX‐2 and EP2 in survivin expression following UVB exposure of mouse skin was investigated. In wild type mice,...
Molecules targeting pro‐inflammatory pathways have demonstrated beneficial effects in cancer treatment. More recently, combination of natural and synthetic anti‐inflammatory drugs was suggested as an appealing strategy to inhibit tumor growth. Herein, we show that curcumin, a polyphenol from Curcuma longa and celecoxib induce apoptosis in hematopoietic cancer cell lines (Hel, Jurkat, K562, Raji, and...
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