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c4 is a derivative of the mouse hepatoma cell line, Hepa‐1, that harbors a mutation in the aryl hydrocarbon receptor nuclear translocator gene (Arnt, or hypoxia inducible factor 1β [HIF‐1β]) leading to loss of activity. Clone 3 cells were generated by introducing a doxycycline‐repressible Arnt expression vector into c4 cells. Clone 3 cells were injected subcutaneously into immunosuppressed mice, which...
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