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Several studies have implicated the feedback activation of signal transducer and activator of transcription 3 (STAT3) as a new cancer drug‐resistance mechanism and linked it to the failure of epidermal growth factor receptor (EGFR)‐targeted therapies. In this study, we discovered that Alantolactone, a natural sesquiterpene lactone, potently inhibited human pancreatic cancer cells and suppressed constitutively...
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