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3,3′‐Diindolylmethane (DIM) is a major acid‐condensation product of indole‐3‐carbinol and is present in cruciferous vegetables. In this study, we evaluated the effects of DIM on antiinflammatory and antitumor promotion activity in mouse skin and explored the relevant mechanisms. When 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) was applied topically to the mouse ear to induce inflammation, DIM pretreatment...
Ample evidence has shown key roles of inflammation in tumor promotion and carcinogenesis, and tumor‐associated macrophages are known to promote tumor growth and dissemination. Programmed cell death 4 (Pdcd4) is a novel tumor suppressor, and although various studies have revealed that the functions and expression mechanisms of Pdcd4 in tumor promotion, those in regard to inflammation remain unclear...
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